已公认有几种致病因素牵连酒渣鼻的发展，其中包括鼻部螨虫、幽门螺旋杆菌等，但肠内细菌的致病因素从来没有被调查过。下面是一片医学论文，他们使用对照实验程序，评估SIBO（小肠细菌过度生长）对酒糟鼻致病效果。
样本为60例酒渣鼻患者（43名女性，17名男性；平均年龄52±15）和60例健康对照者，性别和年龄相匹配。所有患者和对照组进行乳果糖和葡萄糖呼吸试验（BTS），以评估SIBO的存在。SIBO阳性患者随机接受利福昔明1200毫克/10天或安慰剂。在以上基础治疗后，由两个独立的皮肤科医生评估酒渣鼻临床特征。
结果： 与对照组相比，发现了SIBO在酒渣鼻患者中有增加趋势（分别为40／60和3／60，P＜0.001）。在实验组我们得到的皮肤病灶完全恢复在17／20（85%）和2 / 20（10%）患者相关的改善，而安慰剂组保持不变（14 / 16）或甚至恶化（2 / 16），（P＜0001）。这些患者随后切换到利福昔明治疗，得到酒渣鼻14 / 16和显着改进和另外2例的改进。
结论：研究显示在酒渣鼻患者当中SIBO发生率高，而且在临床有效性意义上根除SIBO可使皮肤病变几乎完全缓解。
源自The United European Gastroenterology Week website胡乱翻译的，大家捡重点看，结果那处翻译的不好。还有些是我脑补上去的。原文摘要如下：INTRODUCTION: Several pathogenetic factors have been implicated in the development of rosacea, but the role of intestinal bacteria has never been investigated.
AIMS & METHODS: We aimed at assessing the presence of small intestinal bacterial overgrowth (SIBO) in patients with rosacea and the clinical effectiveness of its eradication.We enrolled 60 consecutive rosacea patients (43 females, 17 males; mean age 52 ± 15) and 60 healthy controls, sex- and age-matched. All patients and controls underwent lactulose and glucose breath tests (BTs), in order to assess the presence of SIBO. Patients positive for SIBO were randomized to receive rifaximin 1200 mg/die for 10 days or placebo.Eradication was assessed with the same BTs after one month of the end of antibiotic therapy. Two independent dermatologists evaluated clinical features of rosacea before and after treatment on the basis of an objective scale.
RESULTS: We found an increased prevalence of SIBO in patients with rosacea compared to controls (40/60 vs 3/60, respectively, p<0.001). Oro-cecal transit time resulted significantly delayed in patients with SIBO than in controls (p<0.01). After SIBO eradication we obtained a complete recovery of cutaneous lesions in 17/20 (85%) and a relevant improvement in 2/20 (10%) patients, while those treated with placebo remained unchanged (14/16) or even worsened (2/16), (p<0,001). These latter patients were subsequently switched to rifaximin therapy with complete resolution of rosacea in 14/16 and significant improvement in the remaining 2 cases.
CONCLUSION: Our study shows the high prevalence of SIBO in patients with rosacea and emphasizes the clinical effectiveness of its eradication in inducing almost complete remission of cutaneous lesions.
http://www.rosaceagroup.org/The_Rosacea_Forum/showthread.php?13631-SIBO-rosacea-link这是国外病友对这篇文章的讨论。
样本为60例酒渣鼻患者（43名女性，17名男性；平均年龄52±15）和60例健康对照者，性别和年龄相匹配。所有患者和对照组进行乳果糖和葡萄糖呼吸试验（BTS），以评估SIBO的存在。SIBO阳性患者随机接受利福昔明1200毫克/10天或安慰剂。在以上基础治疗后，由两个独立的皮肤科医生评估酒渣鼻临床特征。
结果： 与对照组相比，发现了SIBO在酒渣鼻患者中有增加趋势（分别为40／60和3／60，P＜0.001）。在实验组我们得到的皮肤病灶完全恢复在17／20（85%）和2 / 20（10%）患者相关的改善，而安慰剂组保持不变（14 / 16）或甚至恶化（2 / 16），（P＜0001）。这些患者随后切换到利福昔明治疗，得到酒渣鼻14 / 16和显着改进和另外2例的改进。
结论：研究显示在酒渣鼻患者当中SIBO发生率高，而且在临床有效性意义上根除SIBO可使皮肤病变几乎完全缓解。
源自The United European Gastroenterology Week website胡乱翻译的，大家捡重点看，结果那处翻译的不好。还有些是我脑补上去的。原文摘要如下：INTRODUCTION: Several pathogenetic factors have been implicated in the development of rosacea, but the role of intestinal bacteria has never been investigated.
AIMS & METHODS: We aimed at assessing the presence of small intestinal bacterial overgrowth (SIBO) in patients with rosacea and the clinical effectiveness of its eradication.We enrolled 60 consecutive rosacea patients (43 females, 17 males; mean age 52 ± 15) and 60 healthy controls, sex- and age-matched. All patients and controls underwent lactulose and glucose breath tests (BTs), in order to assess the presence of SIBO. Patients positive for SIBO were randomized to receive rifaximin 1200 mg/die for 10 days or placebo.Eradication was assessed with the same BTs after one month of the end of antibiotic therapy. Two independent dermatologists evaluated clinical features of rosacea before and after treatment on the basis of an objective scale.
RESULTS: We found an increased prevalence of SIBO in patients with rosacea compared to controls (40/60 vs 3/60, respectively, p<0.001). Oro-cecal transit time resulted significantly delayed in patients with SIBO than in controls (p<0.01). After SIBO eradication we obtained a complete recovery of cutaneous lesions in 17/20 (85%) and a relevant improvement in 2/20 (10%) patients, while those treated with placebo remained unchanged (14/16) or even worsened (2/16), (p<0,001). These latter patients were subsequently switched to rifaximin therapy with complete resolution of rosacea in 14/16 and significant improvement in the remaining 2 cases.
CONCLUSION: Our study shows the high prevalence of SIBO in patients with rosacea and emphasizes the clinical effectiveness of its eradication in inducing almost complete remission of cutaneous lesions.
http://www.rosaceagroup.org/The_Rosacea_Forum/showthread.php?13631-SIBO-rosacea-link这是国外病友对这篇文章的讨论。
大豆好厉害，我看着英文就晕
